The museum building, as well as the display cases, were designed by the Tbilisi based architect of Polish origin Aleksander Szymkiewicz specifically for the silk museum in 1890-92, and it has survived to this day without any major changes. The building is distinguished by its original architecture, which is a fusion of various traditions. The interior is decorated with sculptural elements on the theme of silk, which emphasizes the uniqueness of this building. Since 2006, the building has been recognized as a cultural heritage monument of national importance.
In 2020-2024, a complete restoration of the museum building was carried out. The author of the project is architect Nino Tchachkhiani. The project was co-funded by The International Association of Francophone Mayors.